X-ray crystal structure of JNK2 complexe
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Andreas Kuglstatter; Manjiri Ghate; Stan Tsing; Armando G. VillaseΓ±or; David Sha
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Article
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2010
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Elsevier Science
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English
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JNK2 and p38a are closely related mitogen-activated protein kinases that regulate various cellular activities and are considered drug targets for inflammatory diseases. We have determined the X-ray crystal structure of the clinical phase II p38a inhibitor BIRB796 bound to its off-target JNK2. This s