Influence of operating temperature and p
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Henry H. Y. Tong; Boris Y. Shekunov; Peter York; Albert H. L. Chow
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Article
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2008
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John Wiley and Sons
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English
β 101 KB
Precipitation of pure polymorphic forms (I and II) of salmeterol xinafoate (SX) in supercritical fluids was investigated as a function of operating pressure and temperature. It has been shown that the formation of each polymorph is governed by both thermodynamic shift and kinetic effects, which are