On the presence of mononuclear leucocytes in dorsal root ganglia following transection of the sciatic nerve

✍ Scribed by Smith, Marshall L. ;Adrian, Erle K.

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 449 KB
• Volume: 172
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1091720311

✦ Synopsis

To label circulating blood mononuclear cells, adult male mice were given multiple injections of tritiated thymidine on the day prior to transection of the right sciatic nerve. These animals and uninjured controls that received a similar sequence of tritiated thymidine injections were sacrificed at intervals up to 64 days following the injury. In the dorsal root ganglia associated with the injured sciatic nerves there were more satellite cells per neuron at all time intervals after the first day than were in the ganglia from the uninjured nerves. The percentage of satellite cells that were labeled was also higher in the ganglia from the injured nerves at all times after injury except the first day. Because no tritiated thymidine should have been available at the time of injury or afterward to label cells proliferating in response to the injury, most of the labeled cells in these ganglia must have been cells labeled before the injury or must be derived from such cells through division. The only large population of labeled cells available to the ganglion was that of the labeled blood mononuclear leucocytes, and the increase in number of labeled cells in the injured ganglia is attributed to infiltration of these cells.