Mechanistically diverse enzyme superfami
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John A Gerlt; Patricia C Babbitt
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Article
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1998
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Elsevier Science
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English
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The strategy that nature has used to evolve new catalytic activities from pre-existing enzymes (i.e. retention of substrate binding or of catalytic mechanism) has been controversial. Recent work supports a strategy in which a partial reaction, catalyzed by a progenitor, is retained, and the active-s