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On the Parametric Approach to Survival Data Analysis I. Radiobiological Applications

✍ Scribed by N. O. Kadyrova; Dr. Sci. A. Yu. Yakovlev

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
538 KB
Volume
27
Category
Article
ISSN
0323-3847

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✦ Synopsis

Acute radiation injury and postirradiation recovery have been formalized in terms of a Blarkovian homogeneous process of the rimdom walk with a finite set of states, two absorbing barriers and continuous time. The distribution of time for such a process to reach (for the first time) the upper absorbing barrier was earlier obtained by SAATY (1961) and within the proposed model it coincides with the life span distribution for irradiated animals. The possibilities of finding the maximum likelihood estimates of unknown parameters are investigated by means of simulating experiments performed with a computer assistance. On the basis of simulation results the applicability of the proposed distribution for the purposes of survival data analysis is discussed. Extension of the model to eccomodate two (or more) radiation syndromes is presented.

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