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On the other hand: The stereoselectivity of drug action at ion channels

✍ Scribed by Dr. David J. Triggle

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 451 KB
Volume: 6
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.530060204

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✦ Synopsis

Ion channels are pharmacological receptors with specific drug binding sites. These binding sites define specific structure-function relationships for the actions of drug classes. Interpretation of these structure-function relationships may be complex because of state-dependent drug-channel interactions. These state-dependent interactions determine aflinity and access of drug to binding sites and may result in both quantitative and qualitative changes in structure-function relationships including stereoselectivity. A channelactive drug may exhibit antagonist or activator properties according to membrane potential and the stereoselectivity of interaction may also change with channel state.

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