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On the origin of π-facial diastereoselectivity in nucleophilic additions to chiral carbonyl compounds. 1. Rotational profiles of propionaldehyde 1, chloroacetaldehyde 2, and 2-chloropropionaldehyde 3.

✍ Scribed by G Frenking; K.F Köhler; M.T Reetz

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
757 KB
Volume
47
Category
Article
ISSN
0040-4020

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✦ Synopsis

SummarV

: The conformational profiles for rotation around the C-C(=O) bond a and the energy minimum conformations are calculated for propionaldehyde 1, chloroacetaldehyde 2, MP2/6-3lG(d)//HF/6_3lG(d). and 2-chloropropionaldehyde 3 at a function of a for 1, 2, The energy level of the LUMO is calculated as Felkin-Anh model. and 3 and discussed in relationship to the

📜 SIMILAR VOLUMES

On the origin of π-facial diastereoselec
On the origin of π-facial diastereoselectivity in nucleophilic additions to chiral carbonyl compounds. 2. Calculated transition state structures for the addition of nucleophiles to propionaldehyde 1, chloroacetyldehyde 2, and 2-chloropropionaldehyde 3.
✍ G Frenking; K.F Köhler; M.T Reetz 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 773 KB

Summarv : The transition state structures for addition of LiH to 1, 2, and 3 are computed and analyzed at MP2/6-3lG(d)//HF/6\_3lG(d). Three factors are found to be important for the relative energies of the transition state structures: (i) the conformational energy of the aldehyde; (ii) the interac