In most studies of molecular evolution, the nucleotide base at a site is assumed to change with the apparent rate under functional constraint, and the comparison of base changes between homologous genes is thought to yield the evolutionary distance corresponding to the siteaverage change rate multip
On the Nearest Neighbour Interchange Distance Between Evolutionary Trees
โ Scribed by Ming Li; John Tromp; Louxin Zhang
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 248 KB
- Volume
- 182
- Category
- Article
- ISSN
- 0022-5193
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โฆ Synopsis
We present some new results on a well-known distance measure between evolutionary trees. The trees we consider are free 3-trees having n leaves labeled 0, . . . , n -1 (representing species), and n -2 internal nodes of degree 3. The distance between two trees is the minimum number of nearest neighbour interchange (NNI) operations required to transform one into the other. First, we improve an upper bound on the nni-distance between two arbitrary n-node trees from 4n log n (Culik & Wood, 1982, Inf. Pro. Letts. 15, 39-42) to n log n. Second, we present a counterexample disproving several theorems in (Waterman & Smith, 1978, J. theor. Biol. 73, 789-800). Roughly speaking, finding an equal partition between two trees does not imply decomposability of the distance finding problem. Third, we present a polynomial-time approximation algorithm that, given two trees, finds a transformation between them of length O(log n) times their distance. We also present some results of computations we performed on small size trees.
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