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On the metal ion (Zn2+, Cu2+) coordination with beta-amyloid peptide: DFT computational study

✍ Scribed by T. Marino; N. Russo; M. Toscano; M. Pavelka


Book ID
107661897
Publisher
International Association of Scientists in the Interdisciplinary Areas
Year
2010
Tongue
English
Weight
425 KB
Volume
2
Category
Article
ISSN
1913-2751

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## Abstract In this DFT study, a mechanism of the oxidation of methionine (Met) amino acid residue catalyzed by the metal (Cu^2+^, Zn^2+^, and Fe^3+^) bound amyloid beta (AΞ²) peptide has been proposed. Based on experimental information, two different mechanisms: (1) stepwise and (2) concerted mecha