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On the Mechanisms of Growth Cone Locomotion: Modeling and Computer Simulation

โœ Scribed by Guo-Hua Li; Cheng-De Qin; Mao-Hui Li

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
349 KB
Volume
169
Category
Article
ISSN
0022-5193

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โœฆ Synopsis

In this paper we put forward a model for growth-cone locomotion in which the actin cytoskeleton is represented by a two-dimensional contractile network and the growth-cone membrane is represented by contractile segments coupled with the actin network. Our computer simulation suggests that many mechanisms, such as the actin polymerization and depolymerization, the attachment of actin filaments to the substratum, the transformation of the growth-cone neck into the axon. and the axonal transport, co-operate to generate growth-cone movement.

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