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On the mechanism of the rearrangement of N-aryl α,α-dichloroketimines with lithium aluminium hydride

✍ Scribed by Norbert De Kimpe; Roland Verhé; Laurent De Buyck; Niceas Schamp


Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
305 KB
Volume
92
Category
Article
ISSN
0037-9646

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6-O-Demethylation of the Thevinols with
✍ Simon W. Breeden; Andrew Coop; Stephen M. Husbands; John W. Lewis 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 German ⚖ 59 KB 👁 1 views

In the pursuit of ring-constrained analogues of buprenorphine, we wished to prepare 6-O-demethylated analogues of the thevinols and orvinols. Previously it had been disclosed that lithium aluminum hydride (LAH) in THF containing a chlorinated solvent could achieve this transformation. Here we report