On the Mechanism of the Copper-Catalyzed
โ
Torben Rasmussen; Jakob F. Jensen; Niels รstergaard; David Tanner; Tom Ziegler;
๐
Article
๐
2002
๐
John Wiley and Sons
๐
English
โ 235 KB
๐ 2 views
The selectivity-determining step in enantioselective copper-catalyzed cyclopropanation with diazo compounds has been studied by experimental and computational methods. The addition of the very reactive metallacarbene intermediate in an early transition state to the substrate alkene is concerted but