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On the mechanism of isomerization of cephalosporin esters

✍ Scribed by Wolfgang F. Richter; Yong H. Chong; Valentino J. Stella

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
205 KB
Volume
79
Category
Article
ISSN
0022-3549

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The Degradation Mechanism of an Oral Cephalosporin: Cefaclor
✍ Bartolomê Vilanova; Josefa Donoso; Francisco Muñoz; Francisco García-Blanco 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 German ⚖ 521 KB

## Abstract The degradation of cefaclor (1), an oral cephalosporin antibiotic, was studied at 37° in a neutral aqueous medium by HPLC and ^1^H‐NMR. Under these conditions, 1 underwent intramolecular aminolysis by the 7‐side‐chain NH~2~ group on the β‐lactam moiety to give a piperazine‐2,5‐dione. Th