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On the mechanism of hydrolysis of the triazolobenzodiazepine, triazolam. Spectroscopic study

✍ Scribed by R. M. Jiménez; E. Domínguez; D. Badía; R. M. Alonso; F. Vicente; L. Hernández

Book ID
112128532
Publisher
Journal of Heterocyclic Chemistry
Year
1987
Tongue
English
Weight
251 KB
Volume
24
Category
Article
ISSN
0022-152X

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The influence of cimetidine on the pharmacokinetics of alprazolam and triazolam, two triazolobenzodiazepines metabolized by hepatic microsomal oxidation, was evaluated in a series of healthy volunteers. Subjects ingested single 1.0 mg dose of alprazolam or 0.5 mg doses of triazolam on two occasions,