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On the mechanism of DNA transfection: efficient gene transfer without viruses

โœ Scribed by Coonrod, A; Li, F-Q; Horwitz, M

Book ID
110038104
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
472 KB
Volume
4
Category
Article
ISSN
0969-7128

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## Background: Polyethylenimines (peis) are among the most efficient non-viral gene transfer agents developed so far. however, transfections with these polymers were shown to require a very high copy number of plasmid dna per cell to achieve gene expression. here, we investigate whether it is possi