On the limiting viscosity number of hyaluronate in potassium phosphate buffers between pH 6.5 and 8
✍ Scribed by Endre A. Balazs; Mary K. Cowman; Sara O. Briller; Robert L. Cleland
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1983
- Tongue
- English
- Weight
- 210 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
We have been interested for many years in the conformational behavior of hyaluronate both in the areas of computational and experimental investigation. Reported transitions in conformationally dependent properties such as the limiting viscosity number [q] are of particular importance to us because of their significance for understanding the conformational features of this polymer in its normal state in solution. An example is the dramatic reversible decrease in [q] of hyaluronate with increasing alkalinity a t pH values above about 11. This effect, which can be characterized as a conformational transition, was first reported by Swann' and later