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On the Interaction between a Bactericidal Antibody and a PorA Epitope ofNeisseria meningitidisin Outer Membrane Vesicles: A Competitive Fluorescence Polarization Immunoassay

✍ Scribed by Jean M.H. van den Elsen; Erik van Pomeren; Jan T. Poolman; Jaap Wilting; James N. Herron; Daan J.A. Crommelin


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
123 KB
Volume
247
Category
Article
ISSN
0003-2697

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✦ Synopsis


of the protection against meningococcal disease. We This paper describes a method for determining the focus on the interaction of bactericidal antibody affinity constant (K a ) of the binding between an anti-MN12H2, elicited against PorA subtype P1.7,16, with body Fab fragment and a membrane-embedded proits native outer membrane embedded epitope P1.16 tein epitope under equilibrium conditions. Monothat is located at the apex of PorA surface loop 4 (VR2).