✦ LIBER ✦

On the influence of oxygen and cell concentration in an SFPR whole cell biocatalytic Baeyer–Villiger oxidation process

✍ Scribed by Iris Hilker; Chris Baldwin; Véronique Alphand; Roland Furstoss; John Woodley; Roland Wohlgemuth

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 159 KB
Volume: 93
Category: Article
ISSN: 0006-3592
DOI: 10.1002/bit.20829

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✦ Synopsis

Abstract

Efficient whole cell biotransformations, in particular microbial whole cell Baeyer–Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer–Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. © 2006 Wiley Periodicals, Inc.

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