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On the inadequacy of quinquennial data for analyzing the paternal age effect on Down's dyndrome rates

โœ Scribed by S. H. Lamson; P. K. Cross; E. B. Hook; R. Regal

Book ID
104724372
Publisher
Springer
Year
1980
Tongue
English
Weight
218 KB
Volume
55
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

Investigations of the influence of paternal age on the rate of Down's syndrome are complicated by the high correlation between parental ages and the strong dependence of the incidence rate upon maternal age. Two possible approaches to isolating an independent paternal age effect are shown to lead to erroneous results if based on data by quinquennial age intervals rather than by single-year intervals. For a multiple regression method the discrepancy can be removed by using the mean maternal and mean paternal age within each quinquennial cell. Failure to do so results in an artifactual paternal age effect.

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โœ H. S. Cuckle ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 125 KB ๐Ÿ‘ 3 views

The effect of the choice of maternal age-specific prevalence curve on the model predicted Down syndrome detection rate was examined. All 19 published regression curves from 11 birth prevalence series in four meta-analyses were included. The detection rate for a five per cent false-positive rate was