On the genetics of the Rett syndrome
β Scribed by Hillig, Ulrike
- Book ID
- 122733005
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 372 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0387-7604
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Genetic and nongenetic explanations of femalelimited disease, such as the Rett syndrome, are reviewed, with emphasis on the possibility of a disturbance of late-replicating X-chromosome heterochromatinization. A possible disturbance of X-chromosome late-replication, as demonstrated by BUdR terminal
The origin of Rett syndrome has long been debated, but several observations have suggested an X-linked dominant inheritance pattern. We and others have pursued an exclusion-mapping strategy using DNA from a small number of familial Rett syndrome cases. This work resulted in the narrowing of the regi