On the genetic length of the short arm of the human X chromosome
โ Scribed by H. -H. Ropers; P. Wieacker; T. F. Wienker; K. Davies; R. Williamson
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 372 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0340-6717
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โฆ Synopsis
Published estimates of the length of the human X chromosome are unreliable because they are based on scanty linkage data and complex assumptions about the frequency and distribution of chiasmata in female meiosis. In recent months we have established linkage between restriction fragment length polymorphisms (RFLPs) and several genes on the short arm of the X chromosome. These and previous data can be combined to construct a continuous linkage map spanning the short arm from the Xg gene to the centromere. They suggest that the genetic length of the Xg-Xcen segment may be in the order of 75-90 cM.
๐ SIMILAR VOLUMES
The absence of silver grain precipitation on human chromosome 17, consistently observed in four patients displaying the 17p variant, supports the hypothesis that the 17p variant is a structural heteromorphism rather than translocated satellite material.
An 11-year-old girl with short stature, mental retardation, and mild dysmorphic features was found to have an inverted duplication of most of the short arm of the X chromosome [dic inv dup(X)(qter-->p22.3::p22.3-->cen:)]. Her mother, who is also short and retarded, carries the same duplication. Fluo