✦ LIBER ✦

On the evolution of arginases and related enzymes

✍ Scribed by C. A. Ouzounis; N. C. Kyrpides

Publisher: Springer
Year: 1994
Tongue: English
Weight: 352 KB
Volume: 39
Category: Article
ISSN: 0022-2844
DOI: 10.1007/bf00178255

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✦ Synopsis

Sequence analysis of the arginase/agmatine ureohydrolase family, important enzymes in arginine/agmatine metabolism and the urea cycle, reveals the similarity of arginases to formiminoglutamate hydrolase (hutG) in Klebsiella aerogenes and to a previously unidentified open reading frame adjacent to the HMf locus of the archaebacterium Methanothermusfervidus. The gene structure and distribution of these homologous proteins across primary kingdoms suggest that this family is another example of a primordial enzyme possibly present in the universal common ancestor and that can be used as phylogenetic marker.

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