Efficient resolution of rac-2-cyano-2-me
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Ramón Badorrey; Carlos Cativiela; Marı́a D. Dı́az-de-Villegas; José A. Gálvez
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Article
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2003
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Elsevier Science
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English
⚖ 369 KB
A large laboratory scale synthesis of (S)-a-methylphenylalanine from benzaldehyde and methyl cyanoacetate has been developed. The synthesis is based on the following sequence: (i) preparation of racemic 2-cyano-2-methyl-3-phenylpropanoic acid, (ii) resolution of the enantiomers by crystallisation us