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On the domain construction of the multienzyme gramicidin S synthetase 2 : Isolation of domains activating valine and leucine

✍ Scribed by Hans-Jacob SKARPEID; Trine-Lise ZIMMER; Hans von DÖHREN

Book ID
115127848
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
580 KB
Volume
189
Category
Article
ISSN
1432-1327

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## Abstract Presenilin‐dependent intramembranous proteolysis mediates the dual cleavage of the Notch‐1 protein (S4 and S3) as well as the β amyloid precursor protein (βAPP) (γ40 and ϵ‐site). βAPP has a valine residue just before the γ40 (amyloid β [Aβ] numbering) site and after the ϵ‐site. Both γ40