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On the defect of synthesis ceruloplasmin in the liver polyribosomes in Wilson's disease

✍ Scribed by V. S. Gaitskhoki; O. I. Kisselev; K. A. Moshkov; L. V. Puchkova; M. M. Shavlovski; V. S. Shulman; V. G. Vacharlovski; S. A. Neifakh

Publisher
Springer
Year
1975
Tongue
English
Weight
883 KB
Volume
13
Category
Article
ISSN
0006-2928

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✦ Synopsis

Comparative immunochemical analysis of ceruloplasmin-synthesizing polyribosomes in liver biopsies from control subjects and homozygous carriers of the Wilson's mutation was performed. According to I s 25-antibody binding data, the amount of ceruloplasmin-forming liver polysomes in patients with Wilson's disease was 10-20 times lower than that in non-Wilson patients. Correspondingly, the pulse labeling of ceruloplasmin polypeptides was decreased severalfold in the cell-free liver preparations from patients with Wilson's disease.

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