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On the binding of native plasminogen to fibrin and its role in thrombolysis

✍ Scribed by G.A. Shah; D.P. Dhall

Book ID
119035111
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
272 KB
Volume
32
Category
Article
ISSN
0049-3848

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit