On the analysis of substrate cycles in large metabolic systems
β Scribed by Leiser, J. ;Blum, J. J.
- Book ID
- 112896022
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 814 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0163-4992
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In a previous paper , we presented a model for the analysis of isotopomer distributions of the TCA cycle intermediates resulting from 13 C (or 14 C) labeling experiments. Results allow the rigorous determination of the degree of enrichment at specific carbon atoms of metabolites, of the molecular we
Proper analysis of label distribution in metabolic pathway intermediates is critical for correct interpretation of experimental data and strategic experimental design. While, for example, 13 C nuclear magnetic resonance (NMR) spectroscopy is usually limited to the measurement of degrees of 13 C enri