On the analysis of circular balanced crossover designs
β Scribed by J. Kunert
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 457 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0378-3758
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β¦ Synopsis
The paper considers Aza'is' (J. Roy. Statist. Soc. B, 49 (1987) 334-345) randomization procedure for circular balanced crossover designs. It is shown that this randomization does not justify the assumption of independent identically distributed errors when the estimates are corrected for carryover effects. This might lead to underestimation of the variance of treatment estimates. Similar to the results of Kunert (Biometrics, 43 (1987) 833-845) and Kunert and Utzig (J. Roy. Statist. Soc. B, 55 (1993) 919-927), we give constants, such that multiplication with this constant makes the usual estimate of variance conservative.
π SIMILAR VOLUMES
We describe a program, CROSS, which we have written to obtain potency estimates and other parameters for bioassay data from assays of crossover design. The program permits testing of all assays for statistical validity and calculates the complete analysis of variance for assays of balanced design. T