𝔖 Bobbio Scriptorium
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On the Absolute Configuration of 19-Hydroxy-Prostaglandin B1

✍ Scribed by M. Hamberg


Book ID
115111742
Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
344 KB
Volume
6
Category
Article
ISSN
1432-1327

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## Abstract Doubts that have recently been expressed [1] about the currently accepted (+)‐(__R__), (βˆ’)‐(__S__) [2] absolute configuration of indane‐1‐carboxylic acid appear to be unwarranted. __Our ORD. values for 1‐methylindane [12] are in error__.

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The absolute stereochemistry of the secondary alcohol of the 1,2-dihydroxybutenyl substituent of ciguatoxin (1) was shown to be S by comparing the split CD curve of ciguatoxin tetra-p-bromobenzoate (2) with those of di-and tri-p-bromobenzoates of AB ring fragments that were synthesized enantioselect