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On planning of samples for linkage analysis: Two ways of a sample size reduction

✍ Scribed by E.Kh. Ginsburg; T.I. Axenovich

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
655 KB
Volume
13
Category
Article
ISSN
0741-0395

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✦ Synopsis

The sample size required for a given type I and type I1 errors of linkage decision is determined by using the earlier proposed method of the linkage test power estimation [Ginsburg et al., 19961. Dependence of the sample size on the heterozygotic genotype penetrance is investigated. Two approaches to sample size reduction are considered: the choice of marker gene and the special extension of analyzed pedigree structures. Their effects are quantitatively evaluated in some illustrative situations. It is shown that a practical reduction in sample size can be achieved only when the added part of a pedigree has a special set of phenotypic characteristics in its members. @

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