On-line multidimensional chromatography using packed capillary liquid chromatography and capillary gas chromatography

✍ Scribed by Cortes, H. J. ;Pfeiffer, C. D. ;Richter, B. E.

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 427 KB
• Volume: 8
• Category: Article
• ISSN: 0935-6304
• DOI: 10.1002/jhrc.1240080823

✦ Synopsis

The introduction of selected fractions from a liquid chromatograph into a gas chromatograph has been described; however, analyses were performed by off-line experiments requiring collection and reinjection of the separate fractions or by on-line procedures where disadvantageously, only a fraction of the separated peak or a well resolved component in a mixturecould be introduced into a gas chromatograph. This disadvantage is overcome by the apparatus and method described in this paper, which utilizes a multidimensional chromatography system employing a high efficiency, packed capillary LCcolumn coupled on-line to a capillary gas chromatograph.

The liquid chromatograph (so designed) can act as a highly efficient clean-up or chemical class fractionation step prior to introduction into the gas chromatograph, significantly reducing sample preparation times in many applications. Thus minor components in a complex matrix can be determined without prior sample clean-up, an example of which is the determination of polychlorinated biphenyls in a complex hydrocarbon matrix. * The method and apparatus described in this publication are the subjects of pending patent applications.