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O–N Intramolecular acyl migration strategy in water-soluble prodrugs of taxoids

✍ Scribed by Mariusz Skwarczynski; Youhei Sohma; Maiko Kimura; Yoshio Hayashi; Tooru Kimura; Yoshiaki Kiso


Book ID
108073100
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
167 KB
Volume
13
Category
Article
ISSN
0960-894X

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An eficient and versatile method for the hydrolysis of N-monosubstituted carboxamides has been developed. The method consists of two steps: the conversion to acetoxypivalbnides (190% yield) and their mild alkaline hyakolysis (7040% yield). No epimetization at the oqosition of the acyl group took pla