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On indium(III) chloride-catalyzed aldol reactions of silyl enol ethers with aldehydes in water

✍ Scribed by Shū Kobayashi; Tsuyoshi Busujima; Satoshi Nagayama

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
204 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Contrary to previous reports, it was found that hydrolysis of silyl enol ethers is superior to the desired condensation in lnCl3-catalyzed aldol reactions of silyl enol ethers with aldehydes in water. The reactions were found to proceed in certain amounts in the presence of a catalytic amount of a Lewis acid under neat (solvent-free) conditions, while substrate limitation was observed in these reactions. Use of lnCl3 as a Lewis acid in aldol reactions in micellar systems is also reported.

📜 SIMILAR VOLUMES

The Aldol Reaction of Silyl Enol Ethers
The Aldol Reaction of Silyl Enol Ethers with Aldehydes in Aqueous Media
✍ Shū Kobayashi; Iwao Hachiya 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 238 KB

ne aldol reaction of siIyl enol ethers with aldehydes is \_wccessfuIly carried out in aqueous media by using a lanthsnide trifluoromethanesulfonate as a catalyst. Water soluble aldehydes are applicable and the catalyst can be recovered andreusedin this reaction.