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On Genome-wide Association Studies for Family-Based Designs: An Integrative Analysis Approach Combining Ascertained Family Samples with Unselected Controls

✍ Scribed by Jessica Lasky-Su; Sungho Won; Eric Mick; Richard J.L. Anney; Barbara Franke; Benjamin Neale; Joseph Biederman; Susan L. Smalley; Sandra K. Loo; Alexandre Todorov; Stephen V. Faraone; Scott T. Weiss; Christoph Lange

Book ID
113422813
Publisher
American Society of Human Genetics
Year
2010
Tongue
English
Weight
229 KB
Volume
86
Category
Article
ISSN
0002-9297

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## Abstract We propose a new approach for the analysis of copy number variants (CNVs)for genome‐wide association studies in family‐based designs. Our new overall association test combines the between‐family component and the within‐family component of the family‐based data so that the new test stat