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On Demand Up-regulation of Therapeutic Genes in the Brain: Fiction or Reality?

✍ Scribed by Annamaria Vezzani

Book ID
109138460
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
106 KB
Volume
7
Category
Article
ISSN
1535-7597

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## Abstract It is well established that mediators of peripheral inflammation are relayed to the brain and elicit sickness behavior via neuroinflammatory agents that target neuronal substrates. In the present study, we used double‐stranded RNA (dsRNA), a viral replication intermediate, to mimic the