On computation of the steady-state probability distribution of probabilistic Boolean networks with gene perturbation

A matrix perturbation method for computi

A matrix perturbation method for computing the steady-state probability distributions of probabilistic Boolean networks with gene perturbations

✍ Wei-Wei Xu; Wai-Ki Ching; Shu-Qin Zhang; Wen Li; Xiao-Shan Chen 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 225 KB

Modeling genetic regulatory interactions is an important issue in systems biology. Probabilistic Boolean networks (PBNs) have been proved to be a useful tool for the task. The steady-state probability distribution of a PBN gives important information about the captured genetic network. The computati