On commutator subspaces of GF(pa)SL2(pa)-modules

FGF-2 isoforms of 18 and 22.5 kDa differ

FGF-2 isoforms of 18 and 22.5 kDa differentially modulate t-PA and PAI-1 expressions on the pancreatic carcinoma cells AR4–2J: Consequences on cell spreading and invasion

✍ Fabrice Escaffit; Agnès Estival; Claudine Bertrand; Nicole Vaysse; Etienne Holla 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 378 KB

Pancreatic tumors overexpress FGF-2 and t-PA, but the implication of the growth factor in t-PA synthesis and t-PA-dependent tumor invasion remains unknown. FGF-2 is present in different isoforms: The 18 kDa FGF-2 is secreted, while the 22.5 kDa one is nuclearized and exerts intracrine regulations by