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On-column preparation of 1-aminocyclopentane-1-[11C]carboxylic acid

✍ Scribed by Ren Iwata; Tatsuo Ido; Masao Tada

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
524 KB
Volume
46
Category
Article
ISSN
0969-8043

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✦ Synopsis

A new, convenient on-column method using kieselguhr (Extrelut ~, Merck) has been developed for the synthesis of l-aminocyclopentane-1-[ ~ tC]carboxylic acid ([t ~C]ACPC) from [J ~C]HCN. The whole synthetic procedure, including the trapping and reaction of [~ ~C]HCN as well as the following extraction and acid hydrolysis, was remarkably simplified, and the preparation has been successfully accommodated to routine production of [~C]ACPC. The established method provides radiochemically pure [i IC]ACPC in over 60% radiochemical yield within 40 min after the end of bombardment.

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