Role of metabolites for drugs that under
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April C. Braddy; Andre J. Jackson
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Article
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2010
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John Wiley and Sons
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English
β 280 KB
We investigated the effects of dose and intrasubject variability (ISV) on bioequivalence (BE) of a parent drug with a single metabolite formed by nonlinear firstpass. A BE simulation was done using a four-compartment model at doses of 17.5, 35.0, and 70.0 mg. ISV was set at either 10% or 20% for cle