𝔖 Bobbio Scriptorium
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On Assessment of Bioequivalence for Drugs with Negligible Plasma Levels

✍ Scribed by Dr. Jen-Pei Liu; Dr. Shein-Chung Chow


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
655 KB
Volume
35
Category
Article
ISSN
0323-3847

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We investigated the effects of dose and intrasubject variability (ISV) on bioequivalence (BE) of a parent drug with a single metabolite formed by nonlinear firstpass. A BE simulation was done using a four-compartment model at doses of 17.5, 35.0, and 70.0 mg. ISV was set at either 10% or 20% for cle