✦ LIBER ✦

On a heuristic point of view concerning the expression of numerous genes during the cell cycle

✍ Scribed by Stephen Cooper

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 351 KB
Volume: 64
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.571

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The current model of the eukaryotic cell cycle proposes that numerous genes are expressed at different times during the cell cycle. The existence of myriad control points for gene expression leads to theoretical and logical problems for cell cycle control. Each expressed gene requires a control element to appear in a cell‐cycle specific manner; this control element requires another control element and so on, ad infinitum. There are also experimental problems with the current model based on ineffective synchronization methods and problems with microarray measurements of mRNA. Equally important, the efficacy of mRNA variation in affecting changes in protein content is negligible. An alternative view of the cell cycle proposes cycle‐independent, invariant accumulation of mRNA during the cell cycle with decreases of specific proteins occurring only during the mitotic period of the cell cycle. © 2011 IUBMB IUBMB Life, 2011.

📜 SIMILAR VOLUMES

Balanced regulation of microtubule dynam

Balanced regulation of microtubule dynamics during the cell cycle: a contemporary view

✍ Søren S.L. Andersen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB 👁 2 views

Assembly of mitotic and meiotic spindles into an elliptical bipolar shape is an example of morphogenetic processes that involve local chromosomal regulation of microtubule dynamics for proper spatial microtubule assembly. Global microtubule dynamics during the cell cycle and local microtubule dynami

Balanced regulation of microtubule dynam

Balanced regulation of microtubule dynamics during the cell cycle: a contemporary view. BioEssays 21:53–60.

✍ S.L. Andersen Søren 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 9 KB 👁 2 views

The sentence in the last paragraph of the first column should read: ''Interestingly, the concentration of chromosomes required to induce hyperphosphorylation of Stathmin/Op 18 (29) corresponds to a situation in which each chromosome is surrounded by a uniform cube of extract with a sidelength of 20-

Partial characterization of SUVi, a new

Partial characterization of SUVi, a new mammalian gene induced by UV-c and expressed during the S phase of the cell cycle

✍ Silvia Viaggi; Elena Gallerani; Francesco Molina; Michael Nuesse; Gilberto Fronz 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 2 views

Differential expression of T cell differ

Differential expression of T cell differentiation antigens and major histocompatibility antigens on activated T cells during the cell cycle

✍ Yoshiki Matsui; Howard M. Shapiro; Michael J. Sheehy; Lisa Christenson; Donald E 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB

PTHrP and cell division: Expression and

PTHrP and cell division: Expression and localization of PTHrP in a keratinocyte cell line (HaCaT) during the cell cycle

✍ M. H. C. Lam; S. L. Olsen; W. A. Rankin; P. W. M. Ho; T. J. Martin; M. T. Gilles 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 489 KB 👁 2 views

Parathyroid hormone-related protein (PTHrP) is highly expressed in normal skin keratinocytes, and its involvement in growth and differentiation processes in these cells has been implicated by several lines of evidence which include the use of antisense PTHrP (Kaiser et al., 1994, Mol. Endocrinol., 8

Acute cyclophosphamide exposure has germ

Acute cyclophosphamide exposure has germ cell specific effects on the expression of stress response genes during rat spermatogenesis

✍ Adriana Aguilar-Mahecha; Barbara F. Hales; Bernard Robaire 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 187 KB

## Abstract Exposure of male rats to cyclophosphamide, a commonly used anticancer and immunosuppressive drug, has been shown to alter fertility and progeny outcome in a male germ cell phase‐specific manner. The effect of toxicant exposure on male germ cells depends in part on the stress response me