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On a chip demonstration of a functional role for odorant binding protein in the preservation of olfactory receptor activity at high odorant concentration

✍ Scribed by Vidic, Jasmina; Grosclaude, Jeanne; Monnerie, Régine; Persuy, Marie-Annick; Badonnel, Karine; Baly, Christine; Caillol, Monique; Briand, Loïc; Salesse, Roland; Pajot-Augy, Edith

Book ID: 121745788
Publisher: Royal Society of Chemistry
Year: 2008
Tongue: English
Weight: 509 KB
Volume: 8
Category: Article
ISSN: 1473-0197
DOI: 10.1039/B717724K

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Porcine odorant binding protein (pOBP) contains a single disulphide bridge linking residues Cys63 and Cys155. In order to get information on the role played by this crosslink in determining the structural and functional properties of the protein, we substituted these two Cys residues with two Ala re