Omphalocele, advanced maternal age, and fetal morbidity outcomes

✍ Scribed by Hamisu M. Salihu; Donath Emusu; Zakari Y. Aliyu; Bosny J. Pierre-Louis; Charlotte M. Druschel; Russell S. Kirby

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 65 KB
• Volume: 135A
• Category: Article
• ISSN: 1552-4825
• DOI: 10.1002/ajmg.a.30725

✦ Synopsis

Abstract

In this study we wanted to determine if the risk for adverse neonatal outcome among omphalocele‐affected fetuses is increased among older gravidas. This was a retrospective cohort study on live‐born infants with omphalocele delivered in New York State from 1983 through 1999. We compared infants of older (≥35 years) with those of younger (<35 years) mothers with respect to the following fetal morbidity indices: low birth weight and very low birth weight, preterm and very preterm, and small for gestational age. We used adjusted odds ratios to approximate relative risks. Data on a total of 1,010 infants with omphalocele were analyzed. Mean gestational age and birth weight were similar in both maternal age categories: mean ± standard deviation (SD) for infants with omphalocele born to older mothers = 37.4 weeks ± 3.9 versus 38.0 weeks ± 5.1 for those of younger mothers (P = 0.2); mean birth weights ± SD for infants with omphalocele born to older mothers = 2,813 ± 871.1 versus 2,958 ± 809.9 for those of younger mothers (P = 0.08). Also, the two maternal age sub‐groups did not differ with respect to the fetal morbidity outcome: low birth weight (OR = 0.95; 95% CI = 0.60–1.51), very low birth weight (OR = 0.78; 95% CI = 0.36–1.69), preterm (OR = 0.95; 95% CI = 0.58–1.57), very preterm (OR = 0.73; 95% CI = 0.34–1.58), and SGA (OR = 1.00; 95% CI = 0.44–2.27). Thus, advanced maternal age does not appear to be a risk factor for fetal morbidity outcomes among omphalocele‐affected fetuses. This information is potentially useful in counseling affected parents. © 2005 Wiley‐Liss, Inc.