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Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

✍ Scribed by Diane M Tasset; Mark F Kubik; Walter Steiner


Book ID
115628135
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
374 KB
Volume
272
Category
Article
ISSN
0022-2836

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The binding of a series of low-molecular-mass, active-site-directed thrombin inhibitors (399 -575 Da) to human ␣-thrombin was investigated by surface plasmon resonance technology (BIACORE), stopped-flow spectrophotometry, and isothermal titration microcalorimetry (ITC). The equilibrium constants K D