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Oligonucleotide Analogues with Integrated Bases and Backbone. Part 21 : Influence of the Hydrogen-Bonding Motif on the Gelation of Self-Complementary A*[s]U(*) Dinucleosides

✍ Scribed by Nicolas Bogliotti; Andrea Vasella

Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
409 KB
Volume
92
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

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Gelation of organic solvents by the A*[s]U^(^*^)^ dinucleosides 1 and 2 requires the formation of linear associates cross‐linked by H‐bonding involving either the nucleobase or HOCH~2~C(6/I). This is evidenced by the absence of gel formation of the N^6^‐methyladenosine analogue 5 of 1 and the dehydroxy analogue 4 of 2.

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Oligonucleotide Analogues with Integrate
Oligonucleotide Analogues with Integrated Bases and Backbones. Part 25 : Structural Effects on the Gelation of Self-Complementary A*[s]U Dinucleosides
✍ Nicolas Bogliotti; Andrea Vasella 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 German ⚖ 578 KB

## Abstract The ability of A\*[s]U dinucleosides to gel organic solvents and water is modulated by changing the nature of the substituents at __O__C(2′) and __O__C(3′), as evidenced by comparing the gelation of the dinucleosides **7**–**9** and the properties of the gels. A mere extension of the