We recently reported that murine MethA mutant but not wild-type p53 specifically binds to MAR-DNA elements (MARs) with high affinity. Here we show that this DNA binding activity is exerted not only by MethA mutant p53 but also by other murine mutant p53 proteins isolated from the transformed murine
โฆ LIBER โฆ
Oligomerization of p53 upon Cooperative DNA Binding: Towards a Structural Understanding of p53 Function
โ Scribed by Patrick Chene; Wolfgang Jahnke
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 92 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0044-8249
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The tumor suppresser protein p53 has been called the "guardian of the genome." DNA damage induces p53 to either halt the cell cycle, allowing for repair, or initiate apoptosis. P53 is mutated in over 50% of human tumors and it has been proposed that many tumorigenic mutations are deleterious to p53