Oligomeric interactions of TGF-β and BMP receptors
✍ Scribed by Marcelo Ehrlich; Orit Gutman; Petra Knaus; Yoav I. Henis
- Book ID
- 113622893
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 987 KB
- Volume
- 586
- Category
- Article
- ISSN
- 0014-5793
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## Abstract The nature and role of cell surface proteins that bind members of the TGF‐β family has been investigated. TGF‐β, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF‐β system, these receptors are implicated in the mediation of multiple responses.
The transforming growth factor-beta (TGF-beta) superfamily includes more than 30 members which have a broad array of biological activities. TGF-beta superfamily ligands bind to type II and type I serine/threonine kinase receptors and transduce signals via Smad proteins. Receptor-regulated Smads (R-S