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Oligomeric Aβ affects cell function in NGF-differentiated PC12 cells

✍ Scribed by Linda M. Rowse; M. Desiree Watson; Glenn K. Walker; Mark R. Emmerling; Harry X. LeVine; Roy D. Schwarz

Book ID
117411882
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
191 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract In vivo, the neurotoxin MPTP is oxidated to MPP^+^, which is toxic to dopaminergic neurons. In this paper, we have used MPP^+^ as a tool to evoke neurotoxicity in the PC12 cell line and investigate the intracellular events that are involved. A cytotoxicity test, performed on undifferent