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Olga Aprelikova, Gadisetti V.R. Chandramouli, Matthew Wood, James R. Vasselli, Joseph Riss, Jodi K. Maranchie, W. Marston Linehan, J. Carl Barrett. 2004. Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors. J Cell Biol 92:491–501.

Book ID: 102300360
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 21 KB
Volume: 93
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.20301

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Regulation of HIF prolyl hydroxylases by

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors

✍ Olga Aprelikova; Gadisetti V.R. Chandramouli; Matthew Wood; James R. Vasselli; J 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1α and HIF‐2α) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen