Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide
✍ Scribed by R Rodriguez-Rodriguez; E Stankevicius; M D Herrera; L Østergaard; M R Andersen; V Ruiz-Gutierrez; U Simonsen
- Book ID
- 109839090
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 254 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0007-1188
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📜 SIMILAR VOLUMES
## Abstract Hydroxylamine (0.01–30 mM), a nitric oxide (NO) generator, produced a concentration‐dependent release of [^3^H]dopamine ([^3^H]DA) from rat striatal slices. Hemoglobin (10 μM), a NO scavenger, reduced basal [^3^H]DA release and blocked hydroxylamine (100 μM)‐stimulated [^3^H]DA efflux.
## Abstract Nitric oxide (NO; 1 μM) or an NO donor (500 μM diethylenetriamine‐nitric oxide, DETA‐NONOate) caused rapid glutamate and ATP release from cultured rat cortical astrocytes. NO‐induced glutamate release was prevented by calcium chelators (EGTA or BAPTA‐AM) and an inhibitor of vesicular ex