𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Old EnglishCuþe Folme in Beowulf, Line 1303A

✍ Scribed by Alfred Bammesberger

Book ID
106482073
Publisher
Springer Netherlands
Year
2005
Tongue
English
Weight
163 KB
Volume
89
Category
Article
ISSN
0028-2677

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A de novo MLH1 germ line mutation in a 3
A de novo MLH1 germ line mutation in a 31-year-old colorectal cancer patient
✍ Martina Plasilova; Jian Zhang; Roberta Okhowat; Giancarlo Marra; Markus Mettler; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

## Abstract Hereditary nonpolyposis colorectal cancer is an autosomal dominant cancer predisposition syndrome caused by inherited germ line mutations in DNA mismatch repair genes, predominantly __MSH2__ and __MLH1__. Here we report the first proven de novo germ line mutation in __MLH1__ (c.666dupA)